David Weiner's Biography

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Engineering Immune Potent DNA Vaccines for Difficult Pathogens

Thursday, 21 July 2011 at 09:30

Add to Calendar ▼2011-07-21 09:30:002011-07-21 10:30:00Europe/LondonEngineering Immune Potent DNA Vaccines for Difficult Pathogens SELECTBIOenquiries@selectbiosciences.com

DNA vaccines are an important novel vaccine technology, however the immune responses induced by past generations of DNA vaccines were poor in larger species including nonhuman primates and humans. We have recently utilized a combination of technologies for plasmid optimization, combined with enhanced EP delivery to dramatically improve the immune potency as well as ease of delivery of this platform. We will provide examples in nonhuman primates and report on progress in the clinic of this important enhanced platform. These studies have important implications for the new vaccine approaches to difficult pathogens.