Francesco Marangoni's Biography

Home
|
Registration
|
Submissions
- Submission Guidelines
- Submissions
|
Agenda
|
Exhibition
|
Venue
|
Media
|

Francesco Marangoni, Instructor in Medicine, Massachusetts General Hospital/Harvard Medical School

Francesco Marangoni received his PhD from the Vita-Salute San Raffaele University in Milan, Italy where he studied the regulation of immune responses under the mentorship of Maria Grazia Roncarolo. He subsequently joined Thorsten Mempel’s laboratory at the Massachusetts General Hospital where he pioneered the study of signaling dynamics in T cells using multiphoton intravital microscopy. In 2013 he was promoted to junior faculty member at Massachusetts General Hospital and Harvard Medical School. He is now investigating the dynamics of T regulatory cell activation during the development of cancer and how this in turn promotes unwanted tumor immune privilege.

The Generation of Tumor-Associated T Regulatory Cells Critically Depends on Calcineurin

Wednesday, 2 November 2016 at 16:00

Add to Calendar ▼2016-11-02 16:00:002016-11-02 17:00:00Europe/LondonThe Generation of Tumor-Associated T Regulatory Cells Critically Depends on CalcineurinCancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com

CD4⁺FoxP3⁺ T regulatory cells (T_regs) play a key role maintaining immune homeostasis, yet they are also improperly co-opted by tumors where they blunt anti-tumor immunity and facilitate progression. Treg function is maintained in vivo by continuous triggering of the T cell receptor (TCR), yet it is unknown how interactions between T_regs and APCs in the context of tumor development dynamically trigger the TCR and the numerous signaling pathways downstream of it. Among these, the role of the calcineurin / NFAT pathway in T_reg biology is controversial. We thus investigated the role of calcineurin / NFAT signaling in supporting tumor-associated T_reg (T_uT_reg) generation and function by using mice with Treg-specific deletion of calcineurin B (CnB) and intravital imaging of NFAT activation.

Add to Calendar ▼2016-11-01 00:00:002016-11-02 00:00:00Europe/LondonCancer Immunotherapy and Biofluid Biopsies 2016Cancer Immunotherapy and Biofluid Biopsies 2016 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com

#IMMUNO2016 Tweets

Conference Sponsors