Efficient Detection and Purification of Cell Populations Using RNA SwitchesFriday, 7 December 2018 at 08:30 Add to Calendar ▼2018-12-07 08:30:002018-12-07 09:30:00Europe/LondonEfficient Detection and Purification of Cell Populations Using RNA SwitchesCell Therapy Asia 2018 in Kobe, JapanKobe, JapanSELECTBIOenquiries@selectbiosciences.com We developed synthetic RNA switches for isolating specific cell populations derived from human pluripotent stem cells (PSCs). miR-208a-switch efficiently isolated functional cardiomyocytes and a switch encoding the apoptosis inducer Bim enriched for cardiomyocytes without cell sorting. This approach is broadly applicable, as miRNA switches can be programmed for purification of various cell types. Thus, RNA switches could be useful to purify desired cell types for future therapeutic applications and regenerative medicine. |