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Transplantation of Retinal Progenitor Cells to the Diseased Retina

Monday, 21 April 2014 at 09:45

Add to Calendar ▼2014-04-21 09:45:002014-04-21 10:45:00Europe/LondonTransplantation of Retinal Progenitor Cells to the Diseased RetinaClinical Translation of Stem Cells 2014 in Palm Springs, California, USAPalm Springs, California, USASELECTBIOenquiries@selectbiosciences.com

The isolation of retinal progenitor cells (RPCs) and transplantation to the retina of recipients with retinal degenerations has revealed the therapeutic potential of this approach in the setting of otherwise incurable blinding diseases. The mechanism of action can involve trophic-mediated neuroprotection of host photoreceptors or integration into the host retina and differentiation into retinal cell types such as photoreceptors. Much work has been done to distinguish the RPC as a significant therapeutic candidate. The ongoing project extends this work to the GMP production of human RPCs, formal IND-enabling preclinical studies and early clinical trials. There is much to recommend this approach, including simplicity, safety, and particularly the potential for cell-mediated efficacy in currently untreatable blinding diseases.