Conferences \ Molecular Diagnostics Europe \ Disease Biomarkers \ Agenda \ Christoph Turck |
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From Proteomes to Pathways to Biosignatures – Progress Towards Understanding Psychiatric Disorder EtiologyThursday, 10 May 2012 at 10:00 Add to Calendar ▼2012-05-10 10:00:002012-05-10 11:00:00Europe/LondonFrom Proteomes to Pathways to Biosignatures – Progress Towards Understanding Psychiatric Disorder Etiology SELECTBIOenquiries@selectbiosciences.com Proteomic technologies in combination with pathway analysis promise to be of great value in molecular medicine, particularly for the discovery and validation of disease markers. Our biomarker detection efforts range from classical proteomics approaches such as quantitative mass spectrometry of brain tissue and body fluid proteins to in silico analyses of public data. A particular focus is the use of animal models that represent selected endophenotypes characteristic for the respective clinical psychiatric phenotype in humans. A comprehensive and sensitive proteomics platform that is based on metabolic labeling of mouse models with stable isotopes is used for mass spectrometry based analyses of protein levels and turnover. The resulting data can be used to detect disease relevant pathways and identify biosignatures that can be translated into the clinic. |