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SELECTBIO Conferences Discovery Chemistry Congress

Fabrizio Giordanetto's Biography



Fabrizio Giordanetto, Director, Taros Chemicals GmbH & Co KG

Fabrizio Giordanetto graduated with first class honors in Medicinal Chemistry in 2000 from University of Genoa, Italy). He completed his Ph.D. in Computational Medicinal Chemistry in 2003 at University of London, U.K. while working for the chemistry unit of Pharmacia (Pfizer) in Nerviano, Italy. In 2004 he joined the Medicinal Chemistry Department of AstraZeneca in Mölndal (Sweden) where he grew professionally to the position of Principal Scientist in Medicinal Chemistry and Preclinical Project Leader. Since 2013, he has been Director of Medicinal Chemistry for Taros Gmbh, a research-based SME in Dortmund, Germany, where he leads medicinal chemistry activities and discovery projects. During his career, he worked on several drug discovery programs resulting in multiple clinical candidates spanning oncology and cardiovascular indications and >80 peer–reviewed publications, book chapters, and international patents.

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Optimisation of P2Y12 Receptor Antagonists for the Treatment of Arterial Thrombosis: Receptor Kinetics and Pharmacodynamic Relevance

Tuesday, 18 February 2014 at 11:30

Add to Calendar ▼2014-02-18 11:30:002014-02-18 12:30:00Europe/LondonOptimisation of P2Y12 Receptor Antagonists for the Treatment of Arterial Thrombosis: Receptor Kinetics and Pharmacodynamic RelevanceDiscovery Chemistry Congress in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

Antagonism of the P2Y12 receptor results in successful anti-platelet aggregation therapies. The lead optimisation of a series of P2Y12 antagonists with respect to anticoagulation effects, physicochemical and absorption profiles is presented. The observed in vivo effects and pharmacodynamic-pharmacokinetic profiles are discussed in light of the recorded P2Y12 receptor kinetic and the emerging structure-kinetic-relationships.


Add to Calendar ▼2014-02-18 00:00:002014-02-19 00:00:00Europe/LondonDiscovery Chemistry CongressDiscovery Chemistry Congress in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com