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SELECTBIO Conferences Drug Discovery & Development

C. Oliver Kappe's Biography



C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz

C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of the Center for Continuous Flow Synthesis and Processing (CC FLOW) at the Research Center Pharmaceutical Engineering GmbH (RCPE). He received his diploma (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his „Habilitation“ in 1998 in organic chemistry and was appointed Associate Professor in 2000. Since 2011 he is Professor for „Technology of Organic Synthesis“ (Organische Synthesetechnologie) at the Institute of Chemistry at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, T. Takahashi, 2008), the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010) and the Federal University of Rio de Janeiro (Rio de Janeiro, Brazil, 2013-2015).

Professor Kappe has an extensive general experience and a 25 year track record in synthetic and physical organic chemistry, process intensification using batch microwave technology and flow chemistry/microreaction technology, communicated in ~400 scientific publications (Research ID, WoS h-Index 72). For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification technologies. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 100.000 € Houska Prize in addition to a number of other awards. In 2015 he was named Fellow of the Royal Society of Chemistry.

C. Oliver Kappe is the Founding Editor and current Editor-in-Chief of the Journal of Flow Chemistry (Springer) and a board member of the Flow Chemistry Society. In addition he has been an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH, 2003-2007) and has served/serves on the Editorial/Advisory Boards of Green Chemistry, Reaction Chemistry & Engineering (RSC), Current Opinion in Green and Sustainable Chemistry (Elsevier), ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer), Journal of Heterocyclic Chemistry (Wiley-VCH) and a number of other journals. For several years he has been teaching courses on flow chemistry for Scientific Update.

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High-Throughput Microwave Chemistry in Silicon Carbide Microtiter Plates

Tuesday, 30 October 2012 at 16:00

Add to Calendar ▼2012-10-30 16:00:002012-10-30 17:00:00Europe/LondonHigh-Throughput Microwave Chemistry in Silicon Carbide Microtiter PlatesSELECTBIOenquiries@selectbiosciences.com

A high-throughput heating platform made out of strongly microwave absorbing silicon carbide (SiC) equipped with 20 cylindrical wells of appropriate dimensions to be fitted with standard HPLC/GC vials serving as reaction vessels is presented. Microwave heating allows rapid and homogeneous heating of the entire plate, with minimal deviations recorded at different positions of the plate or inside the vessels. Utilizing an additional aluminum top plate fixed with six stainless steel bolts the reaction platforms can be heated up to 250 °C and 20 bar applied pressure inside the HPLC/GC autosampler vials. Four SiC plates (80 reactions) can be processed simultaneously by using the corresponding rotor inside the multimode microwave cavity.1 A key advantage of using autosampler vials as reaction vessels is the possibility of direct reaction monitoring, eliminating a transfer step from the reaction vial to the autosampler vial. Apart from its use for the performance of parallel catalyst/solvent screenings and reaction optimization, the SiC blocks were utilized to synthesize whole libraries of chemical compounds within a single multimode microwave run. More related to analytical chemistry applications, the system has been utilized for GC derivatization reactions in forensic laboratories, the enzymatic hydrolysis of protein-bound selenium, for acid-mediated hydrolysis of proteins and peptides, in forced degradations studies involving active pharmaceutical ingredients, and for parallel low-volume sealed vessel microwave-assisted solvent extractions.


Add to Calendar ▼2012-10-30 00:00:002012-10-31 00:00:00Europe/LondonDrug Discovery and DevelopmentSELECTBIOenquiries@selectbiosciences.com