Conferences \ BioProcessing, Biologics & Biotherapeutics Congress \ Downstream Processing \ Agenda \ Nicholas Willoughby |
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Too Big to Bind? Novel Techniques for Separation of Human Embryonic Stem Cells Based on Physical PropertiesThursday, 21 July 2011 at 14:15 Add to Calendar ▼2011-07-21 14:15:002011-07-21 15:15:00Europe/LondonToo Big to Bind? Novel Techniques for Separation of Human Embryonic Stem Cells Based on Physical Properties SELECTBIOenquiries@selectbiosciences.com This work uses techniques such as atomic force microscopy (AFM) to investigate physical properties of different cell types such as elasticity, topography and surface charge. By identifying significant differences in physcial properties between pluripotent cells and their more differentiated progeny, we can develop more simplistic, robust and scalable purification techniques than those currently based upon complex antigen intereactions. By studying variations in elasticity and surface charge properties of different cell types we are able to design separation devices based upon channels and charged surfaces which selectively remove undifferentiated hES cells from a mixed population of cell types. |