Conferences \ Advances in Drug Discovery \ Epigenetics in Drug Discovery \ Agenda \ Amedeo Caflisch |
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Fragment-Based In Silico Discovery Of Potent And Selective Bromodomain InhibitorsMonday, 6 March 2017 at 12:15 Add to Calendar ▼2017-03-06 12:15:002017-03-06 13:15:00Europe/LondonFragment-Based In Silico Discovery Of Potent And Selective Bromodomain InhibitorsSELECTBIOenquiries@selectbiosciences.com We have identified by docking and validated by binding assays and X-ray crystallography several fragments with favorable ligand efficiency for six human bromodomains. Some of these hits have been optimized into nanomolar lead compounds by computer-aided structure-based design. |