On the Consequences of Foreign DNA Insertions into Mammalian GenomesThursday, 8 September 2011 at 09:00 Add to Calendar ▼2011-09-08 09:00:002011-09-08 10:00:00Europe/LondonOn the Consequences of Foreign DNA Insertions into Mammalian Genomes Epigenetics Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com Activity and function of eukaryotic genomes are subject to complex modifications. The fifth nucleotide in DNA, 5-methyldeoxycytidine, is essential in the multitude of regulatory processes whose understanding has become paramount for all fields of genetics and may hold the key in the interactions between the genome and the environment. In this presentation, three aspects of this global topic will be presented: i) The de novo methylation of integrated foreign DNA. ii) Global alterations of DNA methylation patterns upon the insertion of foreign DNA into eukaryotic genomes. iii)A methylation boundary to safeguard the activity of the human FMR1 promoter. |