Tang-Long Shen's Biography

Tang-Long Shen, Professor, National Taiwan University

Professor Shen received his PhD from Cornell University in Cancer Cell Biology. Professor Shen is interested in understanding the molecular mechanism of cancer progression, especially to elucidate how cancer cells migrate, the pre-metastatic niche formation and tumor metastatic organotropism. Professor Shen is Currently Professor, Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.

Tumor Exosomes in Organotropic Metastasis

Friday, 8 April 2016 at 11:15

Add to Calendar ▼2016-04-08 11:15:002016-04-08 12:15:00Europe/LondonTumor Exosomes in Organotropic MetastasisExosomes and Liquid Biopsies Asia 2016 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com

As proposed by Stephen Paget in 1889, the “ seed and soil” hypothesis implicates an organotropic metastasis in cancers. To resolve the specificity of organotropism, we have determined that tumor exosomal integrins are key determinants for guiding organotropic targeting and the sequential Src phosphorylation and pro-inflammatory S100 gene expression happens in the recipient cell. Therefore, a pre-metastatic niche is created for subsequent cancer metastasis. Blocking of exosomal integrins, such as a6ß4 and a6ß1 were associated with lung metastasis, impaired lung metastasis. Together, these data indicate tumor exosomes may be used for prediction and therapeutic targets of cancer metastasis.

Add to Calendar ▼2016-04-07 00:00:002016-04-08 00:00:00Europe/LondonExosomes and Liquid Biopsies Asia 2016Exosomes and Liquid Biopsies Asia 2016 in Taipei, TaiwanTaipei, TaiwanSELECTBIOenquiries@selectbiosciences.com

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