| Conferences \ Genomics Research Europe 2013 \ Epigenetics, microRNAs and non Coding RNAs in Disease \ Agenda \ Hussein Fayyad-Kazan |
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Human CD4+CD25+ Regulatory T Lymphocytes (Tregs): MicroRNA Expression Profile and Effect of Valproate Treatment on microRNA Signature and FOXP3 Expression in their Negative Counterparts (CD4+CD25- T Lymphocytes)Wednesday, 16 October 2013 at 15:00  Add to Calendar ▼2013-10-16 15:00:002013-10-16 16:00:00Europe/LondonHuman CD4+CD25+ Regulatory T Lymphocytes (Tregs): MicroRNA Expression Profile and Effect of Valproate Treatment on microRNA Signature and FOXP3 Expression in their Negative Counterparts (CD4+CD25- T Lymphocytes)SELECTBIOenquiries@selectbiosciences.comRegulatory T cells (Tregs) are a subpopulation of T cells with suppressive properties. We investigated human natural Tregs and identified a signature composed of five miRs. Using lentiviral transduction, we demonstrated that miR-31 and miR-21 had negative and positive effects on FOXP3 expression levels repectively. We thereafter showed that valproate treatment of human non-Tregs confers on them a molecular profile similar to that of their regulatory counterpart. |
Add to Calendar ▼2013-10-16 00:00:002013-10-17 00:00:00Europe/LondonEpigenetics, microRNAs and non Coding RNAs in DiseaseSELECTBIOenquiries@selectbiosciences.com
