Michael Graner,
Professor, Dept of Neurosurgery,
University of Colorado Anschutz School of Medicine
Michael Graner received his PhD in Biochemistry from the University of Illinois followed by post-doctoral and research faculty work at the University of Arizona, shifting gears from the Drosophila extracellular matrix to cancer immunotherapy. He then took at faculty position at Duke University’s Tisch Brain Tumor Center, followed by his current position as Professor in Neurosurgery at the University of Colorado Denver (Anschutz Medical Campus). He is also a member of the University of Colorado Cancer Center, the Colorado Clinical and Translational Sciences Institute, the MAVRC Program, and holds a Visiting Professorship Appointment at the Shenzhen Third People’s Hospital (China) and an adjunct faculty appointment at Colorado State University. Graner has a long-standing interest in cell stress responses, which led to cancer vaccine development (including one in clinical trials), which somehow led to the world of extracellular vesicles (EVs). His lab currently concentrates on signaling mechanisms involving EVs, in particular the transfer of stressed phenotypes from stressed tumor cells to unstressed ones via EVs.
The HSP-Accessorized Exosome: Presence in States of Danger, Disease, and Disruption
Thursday, 28 March 2019 at 15:00
Add to Calendar ▼2019-03-28 15:00:002019-03-28 16:00:00Europe/LondonThe HSP-Accessorized Exosome: Presence in States of Danger, Disease, and DisruptionExtracellular Vesicle-based Dx and Rx Summit in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Heat shock proteins (HSPs) function as chaperones under both normal and
pathologic conditions. As chaperones they assist in protein folding, in
holding protein complexes for current or future activation, and in the
degradation of senescent proteins for recycling of components and
display for immune surveillance. During stressful situations, HSP
quantities and/or activities are increased as cells and tissues seek
protection from insults. On occasion, these insults can result in the
cell surface display of HSPs, which can then lead to the surface display
of HSPs on exosomes, membrane-enclosed vesicles released
extracellularly after passage thru the endosomal system. HSPs present on
the cell surface or in the extracellular space are regarded as “danger
signals” in an ancient biologic paradigm. HSP-accessorized exosomes may
act as “danger boli”, carrying not only the HSPs, but hundreds of
components of the stressed parental cell, capable of prompting immune
responses, or possibly immune suppression, depending on the status of
the recipient cell. Here we show that exosomes from the blood of
patients suffering from neurologic maladies (cancer, brain injury,
multiple sclerosis) are precipitated by peptides designed to bind HSPs.
The metabolome of such exosomes is distinct from that of blood exosomes
from healthy donors. Such HSP-accessorized exosomes possess inflammatory
properties and may serve as biomarkers in a “liquid biopsy” setting.
Add to Calendar ▼2019-03-28 00:00:002019-03-28 00:00:00Europe/LondonExtracellular Vesicle-based Dx and Rx SummitExtracellular Vesicle-based Dx and Rx Summit in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-03-28 15:00:002019-03-28 16:00:00Europe/LondonThe HSP-Accessorized Exosome: Presence in States of Danger, Disease, and DisruptionExtracellular Vesicle-based Dx and Rx Summit in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
