Randolph Corteling's Biography

Randolph Corteling, Head of Research, ReNeuron Ltd.

Randolph started his career as a Research associate at Novartis, before undertaking a PhD in Medical and Surgical Sciences at Nottingham University. He then subsequently spent 3 years as a Heart and Stroke Foundation postdoctoral fellow at the University Calgary, Canada before joining ReNeuron as a senior member of the research team in 2007. During his time at ReNeuron, Randolph has developed a number of new discoveries along with a thorough understanding of stem cell biology leading to his appointment as Head of Cell Biology in 2011 before subsequently being made Head of Research in April 2015.

An Exosome-based Drug Delivery Platform Derived From an Immortalized Human Neural Stem Cell (hNSC) Line

Friday, 1 November 2019 at 14:00

Add to Calendar ▼2019-11-01 14:00:002019-11-01 15:00:00Europe/LondonAn Exosome-based Drug Delivery Platform Derived From an Immortalized Human Neural Stem Cell (hNSC) LineExosomes-EV-based Therapeutics Summit in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

To ensure the scale required for clinical research and commercialisation producer cell immortalisation and clonal isolation is a practical strategy to produce consistent, functionally bioactive exosomes for use as therapeutic agents. Immortalisation ensures production stability and reduces the need for equivalence testing.

CTX0E03 is a conditionally immortalised human neural stem cell line that has been manufactured to clinical-grade (GMP) standards, using a 3-tier banking strategy and is currently in Phase IIb clinical evaluation for disability after stroke. Using the conditioned media produced during GMP manufacture, we have shown that CTX0E03 is an abundant producer of exosomes that can be readily isolated and purified at scale. The CTX cell line can also be rapidly and efficiently modified to direct the expression of a variety of cargoes within the secreted EV population, whilst maintaining the key immortalised stem cell characteristics of the parental cell line. The natural tissue tropism of CTX-derived exosomes can then be exploited to deliver loaded cargoes to target cells.

Add to Calendar ▼2019-11-01 00:00:002019-11-01 00:00:00Europe/LondonExosomes-EV-based Therapeutics SummitExosomes-EV-based Therapeutics Summit in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

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