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SELECTBIO Conferences Extracellular Vesicles 2023: Drug Delivery, Biologics & Therapeutics

Damien Pearse's Biography



Damien Pearse, Professor, Department of Neurological Surgery; The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies, University of Miami Miller School of Medicine

Dr. Pearse is a Professor at The Miami Project to Cure Paralysis, Department of Neurological Surgery at the University of Miami Miller School of Medicine. Dr. Pearse is also a Research Health Scientist at the Bruce Carter Miami VA Healthcare System. Dr. Pearse received his undergraduate degree in Biotechnology and doctorate in Neuroscience from Griffith University, Queensland, Australia. Following a postdoctoral fellowship at The University of Miami, Dr. Pearse joined the faculty. Dr. Pearse was an associate in the Christopher and Dana Reeve Foundation Consortium from 2000 to 2006 and in 2005 received the Erica Nader Award for being the Outstanding Investigator in SCI Research from the American Spinal Injury Association. Dr. Pearse is currently The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies where his work is focused on the translation of autologous cell therapies for neural repair following spinal cord injury and other neurological disorders.

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Glial Cell-Derived EVs for Axon Growth and Neurorepair

Thursday, 27 July 2023 at 10:00

Add to Calendar ▼2023-07-27 10:00:002023-07-27 11:00:00Europe/LondonGlial Cell-Derived EVs for Axon Growth and NeurorepairExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com

Extracellular vesicles (EVs), particularly exosomes, are important cell-to-cell communication vehicles for influencing target cell behavior both locally and at a distance through their delivery of microRNA and protein cargoes. EVs can be readily harvested from cultured human and rodent glial cells in large yields for potential therapeutic use in neurological diseases and neurotrauma where their affects include favorable immunomodulation, anti-inflammatory activities, suppression of cell death, directed cell differentiation and the stimulation of axon growth and neuroplasticity. Here we will report on our work in which we have identified that EVs derived from Schwann cells and phenotypically converted microglia can promote axon growth of CNS neurons. We will also discuss the utility of glial cell-derived EVs as therapeutic vehicles for spinal cord injury (SCI) protection and repair.


Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Drug Delivery, Biologics and TherapeuticsExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com