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SELECTBIO Conferences Extracellular Vesicles 2023: Drug Delivery, Biologics & Therapeutics

Nazli Khodayari's Biography

Nazli Khodayari, Assistant Professor, Department of Medicine, University of Florida

I am a research assistant professor, highly motivated in the pursuit of a career in academic translational research. My research mainly centers on alpha-1 antitrypsin deficiency-mediated tissue injury. I began my contribution to the field by developing a knockout hepatocyte cell line for alpha-1 antitrypsin and have made several contributions to the field, including identifying ERdj3 as key cochaperone to alpha-1 antitrypsin degradation and exosome mediated unconventional secretion as a novel alpha-1 antitrypsin degradation pathway. More recently, I have made several contributions on the role of mutant alpha-1 antitrypsin accumulation in the macrophages function during both liver and lung inflammation.

My current studies focus on 1) phenotyping plasma circulating exosomes in alpha-1 antitrypsin deficiency, 2) chronic liver disease, 3) alpha-1 antitrypsin deficiency-mediated lung inflammation, and 4) cigarette smoke-induced macrophage’s dysfunction. Central to these studies is the immunological and pathological investigation of extracellular vesicles in vitro and in vivo. My independent research program is focused on understanding this question as well as identifying novel regulators of alpha-1 antitrypsin-mediated liver fibrosis with the ultimate goal of identifying new targets to treat liver fibrosis.

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Extracellular Vesicles-mediated Organ Crosstalk in Systemic Inflammatory Disorders

Thursday, 27 July 2023 at 17:15

Add to Calendar ▼2023-07-27 17:15:002023-07-27 18:15:00Europe/LondonExtracellular Vesicles-mediated Organ Crosstalk in Systemic Inflammatory DisordersExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando,

Liver has a key role in the modulation of systemic inflammatory responses. It is evidenced that normal liver function exerts lung protection and is necessary for recovery from lung damage. Lung–liver axis is critical for integrating systemic responses and disbalance in this communication can be an important factor in the damage to both organs. EV have been shown to regulate pathophysiological events via their intercellular and inter-tissue transfer of their cargo. In chronic lung inflammatory diseases, changes in the number and content of EV have been reported during exacerbation of the disease. The liver is exposed to EV released by intrahepatic and various extrahepatic cells and organs such as lung through blood circulation. Circulating pro-inflammatory EV can promote liver fibrosis by activating liver immune cells. Here, we investigate the contribution of extrahepatic inflammation in the progression of alpha-1 antitrypsin deficiency-mediated liver disease, by focusing on lung derived proinflammatory EV.

Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Drug Delivery, Biologics and TherapeuticsExtracellular Vesicles 2023: Drug Delivery, Biologics and Therapeutics in Orlando, FloridaOrlando,