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SELECTBIO Conferences Circulating Biomarkers, Exosomes & Liquid Biopsy Europe 2022

Dominique PV de Kleijn's Biography



Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands

Prof. Dr. Dominique PV de Kleijn is molecular biologist and chemist and professor of Exp. Vascular Surgery at UMC Utrecht and professor at the Netherlands Heart Institute. From 2012 to 2016, he was Research Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI) Singapore. He was until 2016 professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht. Since 1997 he is coordinating cardiovascular research from basic science, animal myocardial infarction and atherosclerotic studies (pig and sheep) towards clinical biobanking studies. His research interests are: The innate immune system in cardiovascular disease and atherosclerosis & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles. He has more then 275 publications and a H-factor of 78.

Dominique PV de Kleijn Image

Welcome and Introduction by Conference Chairperson and an Overview of the Field of Extracellular Vesicles, circa 2022

Tuesday, 1 March 2022 at 09:00

Add to Calendar ▼2022-03-01 13:00:002022-03-01 14:00:00Europe/LondonPlasma Extracellular Vesicles for Cardiovascular DiseaseCirculating Biomarkers, Exosomes and Liquid Biopsy Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Plasma Extracellular Vesicles for Cardiovascular Disease

Tuesday, 1 March 2022 at 13:00

Add to Calendar ▼2022-03-01 13:00:002022-03-01 14:00:00Europe/LondonPlasma Extracellular Vesicles for Cardiovascular DiseaseCirculating Biomarkers, Exosomes and Liquid Biopsy Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Cardiovascular Disease (CVD) is with the cardiovascular events of Ischemic Heart Disease and Stroke, the number 1 and 2 cause of death in the world and expect to increase especially in Asia. In this presentation we use plasma extracellular vesicle (EV) protein content of vesicles from plasma subfractions on plasma of stroke and TIA patients after carotid atherectomy (CEA). AtheroExpress the large ongoing CEA biobank gives us the unique possibility to compare the different biomarker sources of EV, plasma and carotid plaque in association with onset symptoms and risk of a second Major Adverse Cardiovascular Event (MACE: myocardial infarction, stroke or cardiovascular death). We also evaluated if EV proteins could contribute to identification  of patients at high risk for  MACE or Major Adverse Limb Event (MALE: repeated surgery or limb amputation) after surgery in Peripheral Artery Disease (PAD) patients. Identification of such high risk patients is very important for possible (expensive) add-on pharmaceutical therapy or the decision to operate or not.


Add to Calendar ▼2022-03-01 00:00:002022-03-02 00:00:00Europe/LondonCirculating Biomarkers, Exosomes and Liquid Biopsy Europe 2022Circulating Biomarkers, Exosomes and Liquid Biopsy Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com