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SELECTBIO Conferences Fragment Based Lead Discovery

Andreas Heine's Biography



Andreas Heine, Head, Philipps University Marburg

Since 2002 Head of X-ray crystallography in the laboratory of Prof. G. Klebe, Institute of Pharmaceutical Chemistry, Philipps-University Marburg 1999-2002 Assistant Professor in the Department of Molecular Biology, The Scripps Research Institute, La Jolla. 1993-1999 Post-doc at the Scripps Research Institute, La Jolla in the laboratory of Prof. I.A. Wilson. 1993 Richard-Zsigmondy Award” for doctoral dissertation 1990-1993 Doctoral thesis: Synthesis and structure investigation of metastable reaction intermediates. Advisor Prof. G.M. Sheldrick, Dept. of Inorganic Chemistry, Göttingen University. Master thesis: Crystallization and X-ray structure investigation of boron and nitrogen compounds. Advisor Prof. G.M. Sheldrick, Dept. of Inorganic Chemistry, Göttingen University 1986-1987 University of California at Berkeley recipient of an “Education Abroad Program” fellowship; Reciprocal student at the University of California Berkeley 1983-1990 Chemistry student, Georg-August University Göttingen.

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Design of a Small Fragment Library and its Validation on Endothiapepsin

Wednesday, 20 March 2013 at 11:45

Add to Calendar ▼2013-03-20 11:45:002013-03-20 12:45:00Europe/LondonDesign of a Small Fragment Library and its Validation on EndothiapepsinSELECTBIOenquiries@selectbiosciences.com

A small non rule of 3 compatible fragment library consisting of 364 compounds was designed and validated using endothiapepsin as model protease. A high hit rate was observed, showing different binding modes of various fragment chemotypes.


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonFragment Based Lead Discovery SELECTBIOenquiries@selectbiosciences.com