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Mechanistic Insights and Process Intensification of Aromatic Nitration Based on Flow Chemistry

Sunday, 7 June 2026 at 09:40

Add to Calendar ▼2026-06-07 09:40:002026-06-07 10:40:00Europe/LondonMechanistic Insights and Process Intensification of Aromatic Nitration Based on Flow ChemistryFlow Chemistry Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com

Aromatic nitration, a hazardously complex process, poses serious risks for nearly 200 years. Key challenges include the decoupling of reaction kinetics and transport behavior, the suppression of side reactions, and the improvement of process safety. Flow chemistry offers a powerful integrated tool for both mechanistic exploration and process intensification. By enhancing mass transfer and heat management in continuous flow systems and precisely controlling reaction conditions, a kinetic research methodology for aromatic nitration and kinetic models for typical nitration processes were established. For the first time, a mechanism for suppressing over-nitration side reactions through dynamic regulation of thermodynamic properties in continuous flow system was identified, significantly improving the selectivity of nitration reactions. Furthermore, by integrating the concept of countercurrent flow with flow chemistry principles, a novel microflow reaction mode and its corresponding optimization strategy were developed. This mode reduces the exothermic rate of the nitration reaction while simultaneously increasing the spatiotemporal conversion rate. The flow nitration strategy, combining the novel mechanism and microflow mode, has been successfully applied to various typical nitration processes. It provides a safer and more efficient nitration protocol with higher selectivity, demonstrating the advantages of the proposed strategy.