Timothy Noël's Biography

Timothy Noël, Professor, University of Amsterdam

Timothy Noël received in 2004 his MSc degree (Industrial Chemical Engineering) from the KaHo Sint-Lieven in Ghent. He then moved to Ghent University to obtain a PhD at the Laboratory for Organic and Bioorganic Synthesis (2005-2009). Next, he moved to Massachusetts Institute of Technology (MIT) as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald. At MIT, he worked at the MIT-Novartis Center for Continuous Manufacturing. He currently holds a position as Professor at University of Amsterdam. His research interests are flow chemistry, homogeneous catalysis and organic synthesis.

Go With the Flow, or Not? The Basic Principles of Flow Chemistry for Synthetic Organic Chemists

Friday, 15 November 2019 at 08:30

Add to Calendar ▼2019-11-14 09:00:002019-11-14 10:00:00Europe/LondonCombining Electrochemical Methodology Development With Flow Technology - The Best of Two Worlds?Flow Chemistry Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Consequently, the use of continuous-flow reactors for applications in organometallic and organic chemistry has witnessed a spectacular increase in interest from the chemistry community in the last decade. However, flow chemistry is more than just pumping reagents through a capillary and the engineering behind the observed phenomena can help to exploit the technology’s full potential. Here, we aim to give a concise overview of the most important engineering aspects associated with flow chemistry, such as mixing, heat transfer, multistep reaction sequences, etc. In addition, we will give suitable chemistry examples where appropriate to demonstrate the impact of flow processing on synthetic organic chemistry.

Combining Electrochemical Methodology Development With Flow Technology - The Best of Two Worlds?

Thursday, 14 November 2019 at 09:00

Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat transfer limitations which restraints the scalability of electrochemical methods. Most of the limitations associated with organic electrochemistry can be overcome by performing electrochemical reactions in continuous-flow microreactors. Specifically, the confined dimensions of micro-flow reactors (up to 1 mm internal diameter) allows to reduce the Ohmic drop, to minimize the total amount of supporting electrolytes, and to increase mass transfer from the bulk solution to the electrode surface.

In this lecture, we will describe the development of an electrochemical flow reactor which allows not only to accelerate electrochemical transformations but also to scale the chemistry without the need for reoptimization of the reaction conditions. Furthermore, we will exemplify the versatility of this reactor for a variety of different electrochemical methods developed in our group, including selective oxidation of thioethers and the synthesis of sulfonamides and sulfonyl fluorides.

Add to Calendar ▼2019-11-14 00:00:002019-11-15 00:00:00Europe/LondonFlow Chemistry Asia 2019Flow Chemistry Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

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