Anita Maguire's Biography

Anita Maguire, Professor of Pharmaceutical Chemistry, University College Cork

Anita is a graduate of UCC (BSc 1985, PhD 1989). Following postdoctoral research in Namur, Belgium then in Exeter, UK, Anita returned to UCC in 1991 to establish a research team in synthetic organic chemistry and has played a strategic role at the interface with the pharmaceutical industry. She is a Co-PI in the national SFI Centre SSPC. She was elected as a Member of the Royal Irish Academy in 2014 and appointed RIA Vice President in 2019. She was an Adjunct Professor in the University of Bergen, 2011-16. She was VP Research & Innovation in UCC 2011-21. Throughout her career she has been actively engaged nationally in strategic R&I policy development including as a member of the Advisory Science Council. Since 2015 she is the inaugural Chair of the National Forum on Research Integrity, leading national policy development and implementation in this area.

Telescoping the Synthesis and Reactions of Alpha-Diazocarbonyl Compounds in Flow

Tuesday, 28 March 2023 at 09:00

Add to Calendar ▼2023-03-28 09:00:002023-03-28 10:00:00Europe/LondonTelescoping the Synthesis and Reactions of Alpha-Diazocarbonyl Compounds in FlowFlow Chemistry European Summit 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

While alpha-diazocarbonyl compounds are extremely versatile intermediates in organic synthesis, enabling a wide range of powerful synthetic transformations under relatively mild conditions, their use at scale is limited by safety concerns, in particular in relation to potentially hazardous precursors such as sulfonyl azides or diazoalkanes. Generation of sulfonyl azides in flow and their use in diazo transfer to form a wide range of alpha-diazocarbonyl compounds has been demonstrated through a range of protocols depending on the substrate structure. Furthermore, the successful telescoping of these steps with subsequent transformations including enantioselective transition metal catalysed reactions has been demonstrated. Thus, the synthetic potential of alpha-diazocarbonyl compounds can be accessed without isolating or handling either the sulfonyl azide or the alpha-diazocarbonyl compound.

Add to Calendar ▼2023-03-27 00:00:002023-03-28 00:00:00Europe/LondonFlow Chemistry European Summit 2023Flow Chemistry European Summit 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

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