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SELECTBIO Conferences Flow Chemistry European Summit 2023

C. Oliver Kappe's Biography



C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz

C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of the Center for Continuous Flow Synthesis and Processing (CC FLOW) at the Research Center Pharmaceutical Engineering GmbH (RCPE). He received his diploma (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his „Habilitation“ in 1998 in organic chemistry and was appointed Associate Professor in 2000. Since 2011 he is Professor for „Technology of Organic Synthesis“ (Organische Synthesetechnologie) at the Institute of Chemistry at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, T. Takahashi, 2008), the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010) and the Federal University of Rio de Janeiro (Rio de Janeiro, Brazil, 2013-2015).

Professor Kappe has an extensive general experience and a 25 year track record in synthetic and physical organic chemistry, process intensification using batch microwave technology and flow chemistry/microreaction technology, communicated in ~400 scientific publications (Research ID, WoS h-Index 72). For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification technologies. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 100.000 € Houska Prize in addition to a number of other awards. In 2015 he was named Fellow of the Royal Society of Chemistry.

C. Oliver Kappe is the Founding Editor and current Editor-in-Chief of the Journal of Flow Chemistry (Springer) and a board member of the Flow Chemistry Society. In addition he has been an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH, 2003-2007) and has served/serves on the Editorial/Advisory Boards of Green Chemistry, Reaction Chemistry & Engineering (RSC), Current Opinion in Green and Sustainable Chemistry (Elsevier), ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer), Journal of Heterocyclic Chemistry (Wiley-VCH) and a number of other journals. For several years he has been teaching courses on flow chemistry for Scientific Update.

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Scaling Photochemistry Using Continuous-Flow Technology

Monday, 27 March 2023 at 09:30

Add to Calendar ▼2023-03-27 09:30:002023-03-27 10:30:00Europe/LondonScaling Photochemistry Using Continuous-Flow TechnologyFlow Chemistry European Summit 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Within the synthetic chemistry community, photochemistry has made significant recent impact, with a plethora of novel transformations reported. These take place by irradiation of: the substrate directly; an in situ-generated charge transfer complex; or a metal or organic photocatalyst. The implementation of synthetic photochemistry can already begin to meet the aims of green chemistry through two main principles: a) performing known disconnections under milder conditions, by using photons as a mild and traceless reagent to activate otherwise benign starting materials; b) enabling entirely new disconnections, which can complete target-oriented syntheses in fewer steps, for significant savings in resources, time, energy and waste.

Photochemistry in batch is generally limited by poor light penetration, therefore, scaling up to larger batch reactors is generally impractical. Performing photochemistry in continuous flow has been demonstrated as a widely suitable method to perform photochemical reactions on larger scales. ,  In this presentation a number of illustrative examples of flow photochemistry from our laboratories using different light sources and reactor technologies will be discussed, with special emphasis given to handling solids in flow and the synthesis of Active Pharmaceutical Ingredients (APIs).


Add to Calendar ▼2023-03-27 00:00:002023-03-28 00:00:00Europe/LondonFlow Chemistry European Summit 2023Flow Chemistry European Summit 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com