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SELECTBIO Conferences Formulation and Solubility

John Tsibouklis's Biography



John Tsibouklis, Reader/Director, University of Portsmouth

John is a Reader in Polymer Science at the School of Pharmacy and Biomedical Sciences, University of Portsmouth. His research work is in the areas of Biomaterials and drug delivery. Current research activities include:
• Controlled and targeted drug delivery: design and development of specific retentive delivery systems aimed at mucosal surfaces; nanomaterials for the transport of actives; stimuli-responsive polymer conjugates for the release of therapeutic agents.
• Low-surface-energy materials: synthesis, surface characterisation of polymeric biomaterials with ultra-low surface energies.
• Bioadhesion/mucoadhesion: bioadhesive materials for therapeutic use in the eye, mouth, stomach and colon.
• Bioadhesion control: development of materials that inhibit bacterial binding to biological surfaces and biomaterials.
• Therapeutic agents for targeting cancer tumours: boronated cages for cancer therapy.
• Delivery to the brain: vehicles for the transport of chemotherapeutants across the blood-brain barrier.

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A Simple, Once-a-day Dosage Form for the Delivery of Insulin Through the Nasal Route: in Vitro Assessment and in Vivo Evaluation

Wednesday, 20 March 2013 at 11:15

Add to Calendar ▼2013-03-20 11:15:002013-03-20 12:15:00Europe/LondonA Simple, Once-a-day Dosage Form for the Delivery of Insulin Through the Nasal Route: in Vitro Assessment and in Vivo EvaluationSELECTBIOenquiries@selectbiosciences.com

In vivo experiments (rat model) have demonstrated that an in situ thermogelling formulation of TMC is capable of residing at the nasal mucosa over time scales that far exceed that of mucus turnover. The same formulation has been shown to be capable of effecting the controlled delivery of insulin, as demonstrated by the in vivo (diabetic rat) reduction in blood glucose levels over 24 hours.


Add to Calendar ▼2013-03-19 00:00:002013-03-20 00:00:00Europe/LondonFormulation and SolubilitySELECTBIOenquiries@selectbiosciences.com