Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences High-Content and Phenotypic Screening Europe 2018

Sanjay Sinha's Biography



Sanjay Sinha, BHF Senior Research Fellow, University of Cambridge

Dr Sinha is a BHF Senior Research Fellow at the University of Cambridge. He completed medical training in Cambridge, followed by a PhD in Manchester. Dr Sinha then carried out post-doctoral studies in the USA before founding his group within the WT-MRC Cambridge Stem Cell Institute. He has established novel human pluripotent stem cell (PSC)-based systems to aid developmental studies and generate human models of vascular diseases, in particular Marfan syndrome. He is also investigating novel techniques to regenerate the damaged heart. Dr Sinha is a Cardiologist and he combines his research work with clinical duties at Addenbrooke’s Hospital, Cambridge.

Sanjay Sinha Image

Bridging the Translational Gap: A hiPSC Model of Marfan Syndrome for Drug Discovery

Thursday, 24 May 2018 at 16:00

Add to Calendar ▼2018-05-24 16:00:002018-05-24 17:00:00Europe/LondonBridging the Translational Gap: A hiPSC Model of Marfan Syndrome for Drug DiscoveryHigh-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge, UKSELECTBIOenquiries@selectbiosciences.com

Marfan syndrome is a connective tissue disorder, caused by mutations in FBN1, with pleiotropic manifestations including aortic aneurysms and dissection. Although the angiotensin II receptor blocker, losartan, was effective in treating the disease in mouse models, clinical trials have been much less successful. In this presentation, I will discuss the use of a hiPSC model of aortic disease in Marfan syndrome to understand the molecular basis of this disease and why the mouse studies may not have translated well to patients. I will also describe how this complex in vitro system can be used for novel drug screening for this devastating clinical disorder.


Add to Calendar ▼2018-05-24 00:00:002018-05-25 00:00:00Europe/LondonHigh-Content and Phenotypic Screening Europe 2018High-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge, UKSELECTBIOenquiries@selectbiosciences.com