Automated Patch Clamp Evaluation of Sodium Channel Agonists and AntagonistsWednesday, 28 September 2011 at 12:15  Add to Calendar ▼2011-09-28 12:15:002011-09-28 13:15:00Europe/LondonAutomated Patch Clamp Evaluation of Sodium Channel Agonists and AntagonistsIon Channel Targets in San FranciscoSan FranciscoSELECTBIOenquiries@selectbiosciences.comVoltage-gated Na+ channels present difficulties in developing suitable antagonists, in part, because inhibitory potency is state-dependent, increasing markedly with stimulation intensity. State-dependent block is advantageous in blunting disease-related hyperexcitability, but cannot be accurately detected in conventional binding screens and traditional manual patch clamp techniques are unsuitable to modern drug development. We will present examples of optimized assays on automated platforms for both antagonists (e.g., local anesthetics and anticonvulsants) and agonists (e.g., veratridine and pyrethroid insecticides) suitable for moderate-throughput screening regimens. |
Add to Calendar ▼2011-09-27 00:00:002011-09-28 00:00:00Europe/LondonIon Channel TargetsIon Channel Targets in San FranciscoSan FranciscoSELECTBIOenquiries@selectbiosciences.com
