Molecular Pharmacology of Cardiac Sodium Channels: Impact of Disease-Associated Mutations and Patient-Specific GeneticsWednesday, 28 September 2011 at 10:00  Add to Calendar ▼2011-09-28 10:00:002011-09-28 11:00:00Europe/LondonMolecular Pharmacology of Cardiac Sodium Channels: Impact of Disease-Associated Mutations and Patient-Specific GeneticsIon Channel Targets in San FranciscoSan FranciscoSELECTBIOenquiries@selectbiosciences.comMutations in the principle cardiac sodium channel, NaV1.5, that cause long QT Syndrome variant 3 (LQT-3) confer distinct biophysical properties on expressed channels that allows mutation-specific targeting as a therapeutic approach. Here, in addition to the impact of specific Na+ channel mutations on drug actions, the impact of complex patient-specific genetics on target selectivity will also be discussed using data generated from inducible pluripotent stem cells derived from a LQT-3 family. |
Add to Calendar ▼2011-09-27 00:00:002011-09-28 00:00:00Europe/LondonIon Channel TargetsIon Channel Targets in San FranciscoSan FranciscoSELECTBIOenquiries@selectbiosciences.com
