Mark Burns,
T. C. Chang Professor of Engineering,
University of Michigan
Prof. Mark A. Burns is the T. C. Chang Professor of Engineering and a Professor in both Chemical Engineering and Biomedical Engineering at the University of Michigan. He obtained his MS and PhD degrees in Chemical and Biochemical Engineering from the University of Pennsylvania, and his BS degree from the University of Notre Dame. Prof. Burns has over 350 publications, patents, and presentations. He is a Fellow of the National Academy of Inventors, the American Institute for Chemical Engineers, and the American Institute for Medical and Biological Engineering. He has won numerous awards including the Food, Pharmaceutical, and Bioengineering Division Award from AIChE, and both a Teaching Excellence Award and a Research Excellence Award from the College of Engineering at the University of Michigan. He has also served in a variety of administrative positions at Michigan including Chair of the Chemical Engineering Department, Advisor to the Dean of Engineering, and Executive Director of Mcubed and Research Innovation in the Office of the Vice President for Research.
Biochemical Assays in Variable Height Microfluidic Devices
Monday, 6 May 2024 at 15:00
Add to Calendar ▼2024-05-06 15:00:002024-05-06 16:00:00Europe/LondonBiochemical Assays in Variable Height Microfluidic DevicesInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
Processing of solid particles in 3D-printed fluidic channels has the potential to expand the application space of microfluidic systems. As an example, selective binding of proteins, DNA, and other biological substances is used in assays to detect pathogens, diagnose disease, and guide patient treatment. The capture of these substances can take place in a bulk liquid phase, which is generally simpler, or on a solid surface, which provides the benefit of straightforward two-dimensional result interpretation. We combine these two techniques to achieve the best of both worlds. We use an antibody sandwich assay with the capture antibody immobilized on the solid surface of microbeads, each of which has a specific diameter corresponding to one protein in a multiplexed adsorption assay. The beads are then introduced into a microfluidic channel with varying heights, allowing each bead size to become trapped at a distinct location. This method effectively transforms a three-dimensional suspension into a two-dimensional layout, simplifying the reading of binding results. The channel is currently constructed using a variable etch of a glass substrate in hydrofluoric acid but we hope to use other techniques such as 3D printing to produce these chips. One printing technique we have developed, dual-wavelength stereolithography, could eventually fulfill this goal but the current resolution is too low.
Add to Calendar ▼2024-05-06 00:00:002024-05-07 00:00:00Europe/LondonInnovations in Microfluidics 2024: Rapid Prototyping, 3D-PrintingInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2024-05-06 15:00:002024-05-06 16:00:00Europe/LondonBiochemical Assays in Variable Height Microfluidic DevicesInnovations in Microfluidics 2024: Rapid Prototyping, 3D-Printing in Ann Arbor, MichiganAnn Arbor, MichiganSELECTBIOenquiries@selectbiosciences.com
