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SELECTBIO Conferences Emerging Technologies & Paradigms for In Vitro Dx Europe 2024

Brian Cunningham's Biography



Brian Cunningham, Professor and Intel Alumni Endowed Chair, University of Illinois at Urbana-Champaign

Prof. Cunningham has been a faculty member in the department of Electrical and Computer Engineering and the department Bioengineering at the University of Illinois at Urbana-Champaign since 2004, following a 15-year career in Industry. Prof. Cunningham’s technical focus is the utilization of photonics for biosensing in applications that include life science research, diagnostics, environmental monitoring, and pharmaceutical screening. He has over 90 issued US patents and over 200 peer reviewed journal publications. He is a Fellow of NAI, IEEE, Optica, RSC, AAAS, and AIMBE. He serves as the Director of the Center for Genomic Diagnostics at the Woese Institute for Genomic Biology, and as a Program Leader for the Cancer Center at Illinois on the topic of Cancer Measurement Technology and Data Science. In 2023, his technical contributions were recognized by Optica by the Michael S. Feld Biophotonics Award.

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Ultra-sensitive Digital Molecular and Viral Assays for Point of Care Diagnosis Using Photonic Crystal Biosensor Microscopy

Monday, 18 March 2024 at 09:45

Add to Calendar ▼2024-03-18 09:45:002024-03-18 10:45:00Europe/LondonUltra-sensitive Digital Molecular and Viral Assays for Point of Care Diagnosis Using Photonic Crystal Biosensor MicroscopyEmerging Technologies and Paradigms for In Vitro Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

By combining biosensor microscopy that provides high contrast for detecting individual biomolecules and viruses with novel biochemistry methods that can effectively turn each target molecule into many digitally-counted sensing events, it is possible to achieve attomolar-scale limits of detection for cancer-specific nucleic acid target molecules (miRNA and ctDNA) while simultaneously obtaining thousands-to-one selectivity against single base variants.  The presentation will describe the use of photonic metamaterials and associated detection instruments to amplify optical absorption and fluorescence emission.  The biodetection technology platforms are used to perform assays using nucleic acid strand displacement reactions and CRISPR/Cas chemistry to sense target biomarkers from complex media.  We also utilize DNA origami probes in the shape of hand-like “nano-grippers” that selectively recognize and bind with the outer surface proteins of viruses.  The “amplify-then-digitize” approach represents a new and powerful paradigm for molecular and viral diagnostics, compared to the “digitize-then-amplify” approach utilized in methods such as droplet digital PCR (ddPCR).  Overall, we seek simple, rapid, room temperature, single-step assay methods that can be operate with small, inexpensive, and robust detection systems for applications in point of care diagnostics, laboratory-based diagnostics, and life science research applications.


Add to Calendar ▼2024-03-18 00:00:002024-03-19 00:00:00Europe/LondonEmerging Technologies and Paradigms for In Vitro Dx Europe 2024Emerging Technologies and Paradigms for In Vitro Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com