Sehyun Shin,
Professor & Director, Nano-Biofluignostic Engineering Research Center,
Korea University and Anam/Guro Hospital of Korea University
Professor Shin is currently professor of School of Mechanical Engineering and College of Medicine at Korea University and the director of Nano-Biofluignostic Engineering Research Center. He also has served as the Editor of the Journal of Mechanical Science and Technology (JMST). His research interests include the liquid biopsy for cancer and infectious viruses and the development of microfluidic technologies for disease detection, diagnosis and therapy. He has authored more than 150 peer-reviewed papers and delivered more than 130 invited talks and plenary lectures. He is as the president of International Society of Clinical Hemorheology as well as president of Biomedical Engineering Society of Cardiovascular Diseases. Prof. Shin co-founded three startups which are commercializing technologies developed in his lab. He has garnered many research awards and honors including Presidential citation of Science and Technology Merit by the Korean government, award for the Scientist of the month by NRF, the Academic award of KSME, the Nam-Heon Academic Award for Thermal engineering, Fellow of the ISCH, Fellow of KSME and Fellow of KSOR. Finally, Prof. Shin currently heads a group of 15 researchers.
Novel Multiplexing and Precision Sensing Approaches for Liquid Biopsy
Friday, 30 September 2016 at 16:30
Add to Calendar ▼2016-09-30 16:30:002016-09-30 17:30:00Europe/LondonNovel Multiplexing and Precision Sensing Approaches for Liquid BiopsyLiquid Biopsies and Minimally-Invasive Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Every year, there are about 899,000 new cases and 260,000 mortalities, comprising 6 percent of all cancer deaths globally. Cancer detection is a critical approach for preventing cancer deaths because cases caught early are often more treatable. The development of non-invasive methods to detect and monitor tumors remains a major challenge in oncology. Liquid biopsy such as circulating tumor cells (CTCs), exosomes and circulating tumor DNA (ctDNA) has the potential to provide information about cancers without invasive biopsy. It has been rapidly developing since it yields minimum invasiveness, easy repetitive sampling, and whole mutation representation. These circulating biomarkers can be easily obtained from biofluids such as saliva and blood. Although PCR and NGS (Next Generation Sequencing) based ctDNA detection methods have been introduced, there are still unmet needs to detect ctDNA for clinical applications. We presented a clampSPR (closed-loop amplification PCR-based Surface Plasmon Resonance) sensometry for detecting ctDNAs with multiplexing assay; detect biomolecules with label-free analysis via changes in the refractive index on the sensing film of the SPR sensor in real time. The proposed clampSPR system is similar to real time PCR. After a sample is loaded to the system, it is circulated through a closed-loop channel with passing three different temperature zones by an innovative microfluidic pumping system. Target genes in a sample are amplified as two folds per circulation. Furthermore, encoded hydrogel microparticles were added for multiplexing. This system is fast as 30 minutes for 40 cycles. In addition, it is portable, minimize the sample volume with low cost. Conclusively, our novel approaches can apply to clinical diagnosis of cancer with several advantages such as high sensitivity and multiplexing.
Add to Calendar ▼2016-09-29 00:00:002016-09-30 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2016Liquid Biopsies and Minimally-Invasive Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-09-30 16:30:002016-09-30 17:30:00Europe/LondonNovel Multiplexing and Precision Sensing Approaches for Liquid BiopsyLiquid Biopsies and Minimally-Invasive Diagnostics 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
