Yoon-Kyoung Cho,
Professor, Biomedical Engineering and Dean,
UNIST (Ulsan National Institute of Science & Technology)
Yoon-Kyoung Cho is currently a full professor in Biomedical Engineering and the dean of College of Information and Biotechnology at UNIST, Republic of Korea. She is a member of the National Academy of Engineering of Korea (NAEK), an associate editor of the journal ‘Lab on a chip’, a fellow of the Royal Society of Chemistry, and vice president of the Chemical and Biological Microsystems Society (CBMS). She earned her Ph.D. in Materials Science and Engineering from the University of Illinois at Urbana-Champaign in 1999, following her M.S. and B.S. in Chemical Engineering from POSTECH in 1994 and 1992, respectively. Prior to joining UNIST in 2008, she served as a senior researcher (1999–2008) at Samsung Advanced Institute of Technology (SAIT). Her current research focuses on lab-on-a-chip systems for detecting rare biomarkers, quantitative analysis of cell migration, and systems analysis of intercellular communication. Discover more at http://fruits.unist.ac.kr. https://scholar.google.com/citations?user=Jc1mz_EAAAAJ&hl=en
Liquid Biopsy of Solid Tumors on a Spinning Disc
Thursday, 5 October 2017 at 14:30
Add to Calendar ▼2017-10-05 14:30:002017-10-05 15:30:00Europe/LondonLiquid Biopsy of Solid Tumors on a Spinning DiscLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
In this presentation, our recent efforts on the liquid biopsy application for personalized cancer diagnostics will be discussed in detail. First, we will introduce the fluid-assisted separation technology (FAST), where the size-based separation event occurs not in conventional liquid-gas interface but in liquid-liquid interface stably prepared in a centrifugal microfluidic device. This provides ultrafast, uniform, clog-free, and highly efficient filtration with pressure drop much less than in conventional filtration. We used the FAST mechanism for enriching circulating tumor cells (CTCs) from whole blood without prior sample treatment and could achieve highly sensitive (>95.9% recovery), selective (~3.0 log depletion of white blood cells), rapid (< 3 mL/min), and label-free enumeration of rare CTCs. We demonstrate the clinical utility of the point-of-care detection of CTCs with samples taken from patients suffering from breast, stomach, or lung cancer. Next, we will present a rapid, label-free, and highly sensitive method for Extracellular vesicles (EVs) isolation and quantification using a lab-on-a-disc integrated with two nanofilters (Exodisc). Urinary EVs from bladder cancer patients could be automatically enriched within 30 min using a tabletop-sized centrifugal microfluidic system followed by molecular analysis or on-chip ELISA. We believe that this revolutionary method can contribute to accelerate the acceptance of CTC or EV-based cancer diagnostics as a standard practice in clinical settings.
Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2017Liquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-10-05 14:30:002017-10-05 15:30:00Europe/LondonLiquid Biopsy of Solid Tumors on a Spinning DiscLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
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