Yoon-Kyoung Cho,
Professor, Biomedical Engineering,
Ulsan National Institute of Science & Technology; Group leader, IBS; FRSC, Fellow of Royal Society of Chemistry
Yoon-Kyoung Cho is a full professor of Biomedical Engineering at UNIST and a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS), Republic of Korea. She is a member of the National Academy of Engineering of Korea (NAEK) and a Fellow of Royal Society of Chemistry (FRSC). She serves as a director at the Chemical and Biological Microsystems Society (CBMS) and an associate editor for Lab on a chip. She received her Ph.D. in Materials Science and Engineering from the University of Illinois at Urbana-Champaign (UIUC) in 1999, having obtained her M.S. and B.S. in Chemical Engineering from POSTECH in 1994 and 1992, respectively. She worked as a senior researcher (1999–2008) at Samsung Advanced Institute of Technology (SAIT), where she helped create biomedical in vitro diagnostic instruments. Her research spans a broad spectrum from fundamental scientific exploration to translational efforts, focusing primarily on microfluidics and nanomedicine. Her current research topics include a lab-on-a-disc for the detection of rare cells and biomarkers, quantitative analysis of single cells, and system analysis of cellular communication. She published over 135 journal papers and over 205 issued patents, many of which helped Samsung Electronics and two start-ups (Clinomics and LabSpinner) build commercial products. Discover more at http://fruits.unist.ac.kr.
Liquid Biopsy of Solid Tumors on a Spinning Disc
Thursday, 5 October 2017 at 14:30
Add to Calendar ▼2017-10-05 14:30:002017-10-05 15:30:00Europe/LondonLiquid Biopsy of Solid Tumors on a Spinning DiscLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
In this presentation, our recent efforts on the liquid biopsy application for personalized cancer diagnostics will be discussed in detail. First, we will introduce the fluid-assisted separation technology (FAST), where the size-based separation event occurs not in conventional liquid-gas interface but in liquid-liquid interface stably prepared in a centrifugal microfluidic device. This provides ultrafast, uniform, clog-free, and highly efficient filtration with pressure drop much less than in conventional filtration. We used the FAST mechanism for enriching circulating tumor cells (CTCs) from whole blood without prior sample treatment and could achieve highly sensitive (>95.9% recovery), selective (~3.0 log depletion of white blood cells), rapid (< 3 mL/min), and label-free enumeration of rare CTCs. We demonstrate the clinical utility of the point-of-care detection of CTCs with samples taken from patients suffering from breast, stomach, or lung cancer. Next, we will present a rapid, label-free, and highly sensitive method for Extracellular vesicles (EVs) isolation and quantification using a lab-on-a-disc integrated with two nanofilters (Exodisc). Urinary EVs from bladder cancer patients could be automatically enriched within 30 min using a tabletop-sized centrifugal microfluidic system followed by molecular analysis or on-chip ELISA. We believe that this revolutionary method can contribute to accelerate the acceptance of CTC or EV-based cancer diagnostics as a standard practice in clinical settings.
Add to Calendar ▼2017-10-05 00:00:002017-10-06 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2017Liquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-10-05 14:30:002017-10-05 15:30:00Europe/LondonLiquid Biopsy of Solid Tumors on a Spinning DiscLiquid Biopsies and Minimally-Invasive Diagnostics 2017 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
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