Manabu Tokeshi is a Professor at the Division of Applied Chemistry at Hokkaido University. He is also a Visiting Professor at Innovative Research Center for Preventive Medical Engineering and Institute of Innovation for Future Society at Nagoya University. He received his PhD degree from Kyushu University in 1997. After a research fellow of the Japan Society of Promotion of Science at The University of Tokyo, he worked at Kanagawa Academy of Science and Technology as a research staff (1998-1999), a group subleader (1999-2003), and a group leader (2003-2004). He also worked at the Institute of Microchemistry Technology Co. Ltd. as President (2004-2005) and at Nagoya University as an Associate Professor (2005-2011). In 2011, he visited Karolinska Institutet as a Visiting Researcher and he joined the Hokkaido University as a Professor. His honors include the Outstanding Researcher Award on Chemistry and Micro-Nano Systems from the Society for Chemistry and Micro-Nano Systems (2007), the Pioneers in Miniaturisation Prize from the Lab on a Chip (The Royal Society of Chemistry)/Corning Inc. (2007), the Masao Horiba Award from HORIBA, Ltd. (2011), The Japan Society for Analytical Chemistry Award (2018) and Fellow of Royal Society of Chemistry (FRSC) (2019). His research interests are in the development of micro- and nano-systems for chemical, pharmaceutical and clinical applications.
Fabrication of Engineered Lipid Nanoparticles Using Microfluidic Devices
Thursday, 7 November 2024 at 10:00
Add to Calendar ▼2024-11-07 10:00:002024-11-07 11:00:00Europe/LondonFabrication of Engineered Lipid Nanoparticles Using Microfluidic DevicesLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
Recently, the production of lipid nanoparticles (LNPs) using microfluidic devices has attracted much attention. Microfluidic devices provide many advantages for drug-loaded LNP production, including precise LNP size controllability, high reproducibility, high-throughput optimization of LNP formulation, and continuous LNP-production processes. Various microfluidic devices have been developed and used to produce LNPs encapsulating RNA, DNA, ribonucleoproteins (RNPs), drugs, and others. In fact, microfluidic devices are also being used in the development of Onpattro®, which was approved by the FDA in 2018 as an RNA interference therapeutic drug. Recently, we developed a microfluidic device named iLiNP® (invasive lipid nanoparticle production) device for LNP production based on computational fluid dynamics and LNP formation mechanism. It enabled the LNP size tuning at 10 nm intervals in the size range from 20 to 100 nm. Using this device, we have not only developed pharmaceutical applications by producing LNPs encapsulating nucleic acids and drugs, but also devices integrating the post-processing of LNP production and devices for mass production. Moreover, very recently, we have found that iLiNP devices are also highly suitable for the fabrication of functional (engineered) lipid nanoparticles such as artificial exosomes and virus-like particles. In this lecture I will present these results.
Add to Calendar ▼2024-11-07 00:00:002024-11-08 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024Lab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2024-11-07 10:00:002024-11-07 11:00:00Europe/LondonFabrication of Engineered Lipid Nanoparticles Using Microfluidic DevicesLab-on-a-Chip, Microfluidics, and Organ-on-a-Chip Asia 2024 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
