Microfluidic Tools For Monitoring the Immune SystemThursday, 18 March 2021 at 15:00 Add to Calendar ▼2021-03-18 15:00:002021-03-18 16:00:00Europe/LondonMicrofluidic Tools For Monitoring the Immune SystemInnovations in Microfluidics and SCA 2021 in BostonBostonSELECTBIOenquiries@selectbiosciences.com Microsystems have the potential to impact biology by providing new ways to manipulate, separate, and otherwise interrogate cells. Immune cells are of particular interest because of their central role in defending the body against foreign invaders. As a consequence, many microfluidic devices have been used to study both the basic biology of immune cells as well as to assay them for clinical use. Our lab has developed technologies on both ends of the spectrum, from cell pairing devices able to study information flow in immune cells, to electrical sorting devices for assaying immune cell function in response to disease. In terms of cell pairing, we have developed two complementary approaches to creating programmed pairs of cells, one using capture “cups” and a three-step back-and-forth loading procedure to pair thousands of cells in parallel, and the other using microfluidic “corrals” to contain cells. With these devices we can pair immune cells with each other or with other cells (i.e., tumor cells) to study information flow from first contact to downstream effector functions, elucidating how decision-making occurs in these interactions. |