Multistep Synthesis of API Precursors in Continuous Flow Involving Heterogeneous Palladium CatalysisThursday, 10 September 2020 at 12:15 Add to Calendar ▼2020-09-10 12:15:002020-09-10 13:15:00Europe/LondonMultistep Synthesis of API Precursors in Continuous Flow Involving Heterogeneous Palladium CatalysisMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com Late-stage precursors of the two active pharmaceutical ingredients valsartan and sacubitril have successfully been synthesized in continuous flow using a multistep setup. The key step of the reaction cascades, Suzuki-Miyaura cross coupling, is facilitated by heterogeneous palladium catalysis. |