Dong Pyo Kim,
Changjiang Scholar, Intelligent Microfluidics for Advanced Theranostics Lab,
Harbin Institute of Technology, China
Prof. Kim is a Yangtze River chair professor of HIT-Shenzhen, leading to innovative microfluidics for advanced theranostics from 2025, by shifting from POSTECH in Korea. He obtained a Ph.D. in chemistry and a postdoctoral degree in materials engineering, and worked at a national lab and a university for over 30 years in total, since 1993. His career in microfluidic-based continuous-flow synthetic processes encompasses the manufacturing of APIs and bespoke drug delivery systems, as well as the recent development of AI-based autonomous and integrated processes for biopharmaceuticals. He has published 350 peer-reviewed papers and 50 patents. He received the Academic Excellence Award (2017, Korean Chemical Society), Severo Ochoa Visiting Fellowship (2017, Spain), the POSTECHIAN of the Year (2016, POSTECH), The Scientist of the Month (2016, NRF), Yonsan chaired professor (POSTECH,2017), Henry McGee Lecturer (Virginia State Univ, 2021).
Microfluidic Approaches for Scale-up Chemical Production via Numbering-up & Ultrafast Chemistry
Thursday, 10 September 2020 at 14:00
Add to Calendar ▼2020-09-10 14:00:002020-09-10 15:00:00Europe/LondonMicrofluidic Approaches for Scale-up Chemical Production via Numbering-up and Ultrafast ChemistryMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Continuous-flow technology is emerging for efficient, sustainable and safe synthesis of drug and the precursors. In here, scale-up chemical production are efficiently demonstrated by adopting both approaches of numbering-up microreactors and ultrafast chemical synthesis at high flow rates. Firstly, various numbering-up microreactor systems were designed and manufactured with stainless steel metal or polymer films. The compact and robust reactors demonstrated scale-up production of several drug compounds via azide-alkyne reaction, fast synthesis of organophosphates. Moreover, photocatalysis in a multi-capillary assembly system, 3D printed reactors were used to improve the synthetic productivity. Alternatively, ultrafast synthetic approaches were performed by taming the lithiated flash chemistry in unique microreactors at high flow rates, which envisions facile scale-up production of drugs. Unique design of a chip microreactor enabled submillisecond mixing time even at low temperatures, which was used for outpacing rapid intramolecular rearrangements such as anionic Fries rearrangement to attain high chemoselectivity. And 3D-printed stainless steel microreactor with circular shape of cross-sectional fluidic channel enhanced the intramolecular control for higher yield of the un-rearranged product. Further, a 16 stacked reactor system of circular channel structure with superior mixing efficiency was alternatively devised to synthesize commercial Letrozole drug by newly developed 3 steps route, including ~10 milliseconds of flash chemistry.
Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2020-09-10 14:00:002020-09-10 15:00:00Europe/LondonMicrofluidic Approaches for Scale-up Chemical Production via Numbering-up and Ultrafast ChemistryMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
