Epigenetics and Epigenomics in Health and DiseaseFriday, 20 April 2012 at 10:00  Add to Calendar ▼2012-04-20 10:00:002012-04-20 11:00:00Europe/LondonEpigenetics and Epigenomics in Health and DiseaseSELECTBIOenquiries@selectbiosciences.comDNA methylation plays an important role in cancer and is associated with gene silencing of tumour suppressor genes. The methylation of CpG sites is established by the DNA methyltransferases - the DNMTs. One main interest in our lab is to better decipher the mechanisms by which these enzymes function and participate to cancerogenesis. Another interest is to better understand the involvement of the epigenome in cancers. Indeed, the cancer epigenetic field has evolved from a gene-by-gene approach to more global epigenomic strategies, with far-reaching fundamental and clinical implications. Using such strategies, we have recently performed DNA methylation profiling in human breast tumor tissues. Results will be presented that highlight precise epigenetic portraits in breast cancers, uncovering a key contribution of the DNA methylome to the complexity of the disease. |
Add to Calendar ▼2012-04-19 00:00:002012-04-20 00:00:00Europe/LondonNext-Gen SequencingSELECTBIOenquiries@selectbiosciences.com
