John Castle's Biography

John Castle, Co Director, The Institute for Translational Oncology and Immunology

John Castle originally trained in physics, developing advanced signal processing and statistical inverse theory methodologies to image earthquakes and plate tectonics. He moved to Rosetta Inpharmatics, later part of Merck Sharp and Dohme (MSD), where he contributed to the development of novel computational biology, lab and genomic technologies, including the many of the first NGS experiments in a large pharma. At TRON, he is Co-Director of the Biomarker Development Center and combines immunology, computational biology, and genomics to develop individualized “on-demand” cancer vaccines.