Mass Spectrometry-Based Metabolomics as a Unique Biochemical Approach for Understanding Disease PathogenesisWednesday, 30 September 2015 at 14:30 Add to Calendar ▼2015-09-30 14:30:002015-09-30 15:30:00Europe/LondonMass Spectrometry-Based Metabolomics as a Unique Biochemical Approach for Understanding Disease PathogenesisNGS, SCA, Mass Spec: The Road to Diagnostics in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com Metabolomics, the quantitative global analysis of endogenous metabolites from cells, tissues, fluids and whole organisms, is becoming an integral part of functional genomics efforts as well as a tool for understanding fundamental biochemistry. While the genome and proteome represent upstream biochemical events, metabolites correlate with the most downstream biochemistry and therefore most closely represent the phenotype. This has been proven by the broad success of metabolite analysis in clinical diagnostics. The experimental aim in our studies is to obtain a comprehensive quantitative view of the metabolome to expand our understanding of what pathways are altered in specific diseases. We have developed a novel mass spectrometry platform for metabolomics including XCMS Online data analysis combined with METLIN, a comprehensive MS/MS metabolite database. These technologies will be presented in the context of their application to disease. |