Roger Kamm,
Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering,
Massachusetts Institute of Technology (MIT)
Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization, metastatic cancer and neurological disease. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). For 10 years, he was Director of the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal and the 2015 recipient of the Huiskes Medal, both for lifetime achievements, and was the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010 and Engineering in 2022. Kamm is co-founder of AIM Biotech, a manufacturer of microfluidic systems for 3D culture.
Strategies For in vitro Perfusion of iPSC-derived Organoids: A Tough Nut to Crack
Monday, 22 March 2021 at 09:00
Add to Calendar ▼2021-03-22 00:00:002021-03-22 01:00:00Europe/LondonTitle to be Confirmed.3D-Culture, Organoids and Organs-on-Chips 2021 in SELECTBIOenquiries@selectbiosciences.com
Now that organoids can be generated for a variety of organs and tissues
from induced pluripotent stem cells, there is tremendous interest in
developing methods to connect an external perfusion system to an
internal vasculature. Success in this quest would help facilitate
continuous perfusion, leading to improved viability and functionality of
the developing organ, and supporting the introduction of therapeutics
for drug screening and development. For more than 5 years, we have had
the capability to grow self-assembled microvascular beds, or pattern
small vessels within various hydrogels. Methods are also increasingly
available to induce the growth vascular networks inside of the organoid.
To date, however, it has proved challenging to induce anastomosis
between these two networks and enable continuous perfusion. In this
presentation, different methods will be discussed that hold promise to
address this critical problem.
Add to Calendar ▼2021-03-22 00:00:002021-03-23 00:00:00Europe/London3D-Culture, Organoids and Organs-on-Chips 20213D-Culture, Organoids and Organs-on-Chips 2021 in SELECTBIOenquiries@selectbiosciences.com