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SELECTBIO Conferences Organoids & Organs-on-Chips 2021

Roger Kamm's Biography



Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)

Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). Kamm currently directs the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal (American Society of Mechanical Engineering) and the 2015 recipient of the Huiskes Medal (European Society of Biomechanics), both for lifetime achievements, and is the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010. Kamm is co-founder of two companies, Cardiovascular Technologies and AIM Biotech, a manufacturer of microfluidic systems for 3D culture.

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Closing Keynote Presentation: Developing a Neurovascular Microphysiological System to Model Metastasis to the Brain and Alzheimer’s Disease

Wednesday, 15 December 2021 at 17:15

Add to Calendar ▼2021-12-15 17:15:002021-12-15 18:15:00Europe/LondonClosing Keynote Presentation: Developing a Neurovascular Microphysiological System to Model Metastasis to the Brain and Alzheimer’s DiseaseOrganoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

System complexity is always an important consideration in the context of model design to recapitulate disease processes or for drug development, and few systems pose the array of potentially important cell types and system parameters as are found in the brain.  Over the past several years, we have sought to create models for a variety of applications in neurological function and disease starting with the blood brain barrier and cancer metastasis to the brain, and progressing to various manifestations of Alzheimer’s disease including cerebral amyloid angiopathy, amyloid beta plaque formation, and amyloid clearance from the brain via the meningeal lymphatics. In this talk, I will present the various stages of model development in terms of the essential cell types, the challenges/barriers that arise when adding complexity, and the ways in which each stage of the model is assessed. The emphasis will be on models that draw upon natural self-organization and self-assembly of a diverse cell population into a model with the morphological and functional characteristics of the healthy and diseased brain.


Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonOrganoids and Organs-on-Chips 2021Organoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com