Yan-Jun Liu,
Professor, Institutes of Biomedical Sciences,
Fudan University
Yan-Jun Liu is a Professor at the Institutes of Biomedical Sciences, Fudan University. Her research focuses on microfluidics, organ-on-a-chip, cell microenvironments reconstitution and cell behaviors study. Dr. Liu has made foundational contributions to the field, most notably discovering how confinement and low adhesion trigger the rapid amoeboid transition in traditionally slow mesenchymal cells. She has authored over 50 peer-reviewed publications in leading journals, including Cell, Nature Methods, PNAS, PRL, JACS, Adv. Mater., ACS Nano, Nano. Lett., Anal. Chem., among others. Dr. Liu has served as principal investigator on multiple research projects funded by the National Natural Science Foundation of China (NSFC), the National Key Research and Development Program of China, and the Young Thousand Talents Program. In 2020, she, together with Verena Ruprecht and Andrea Pauli, was awarded the prestigious Human Frontier Science Program (HFSP) Young Investigator Award.
Add to Calendar ▼2026-11-21 15:00:002026-11-21 16:00:00Europe/LondonPersonalized Vascularized Tumor Organoid-on-a-ChipOrganoids and Organs-on-Chips Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
Unraveling tumor complexity is crucial for advancing targeted therapies and personalized medicine. Organoids have emerged as a powerful platform for cancer research due to their ability to recapitulate key aspects of the tumor microenvironment while preserving the genetic, morphological, and pharmacological features of primary tumors. Despite significant progress in culturing patient-derived tumor organoids (PDTOs), a critical limitation remains: the lack of dynamic, tumor-specific vasculature. This is particularly important, as tumor–vascular interactions play central roles in cancer progression, especially metastasis.
Here, we address this gap by developing a vascularized PDTO-on-a-chip platform that enables comprehensive assessment of tumor metastasis and therapeutic responses. By integrating self-assembled vasculature with PDTOs on-chip, we reconstruct hierarchical and heterogeneous tumor-specific microvascular networks in vitro, overcoming the absence of physiologically relevant vascular support in conventional PDTO systems. Notably, the migratory behavior of PDTOs in our platform closely mirrors the metastatic potential observed in corresponding patients, underscoring its value for personalized metastasis assessment. Furthermore, the response of the system to anti-angiogenic therapy is highly consistent with clinical outcomes, demonstrating its utility for preclinical drug evaluation. Ultimately, the system represents a promising avenue for advancing the understanding of tumor metastasis and developing personalized treatment strategies based on patient-specific tumor characteristics.
Add to Calendar ▼2026-11-21 00:00:002026-11-22 00:00:00Europe/LondonOrganoids and Organs-on-Chips Asia 2026Organoids and Organs-on-Chips Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2026-11-21 15:00:002026-11-21 16:00:00Europe/LondonPersonalized Vascularized Tumor Organoid-on-a-ChipOrganoids and Organs-on-Chips Asia 2026 in Shenzhen, ChinaShenzhen, ChinaSELECTBIOenquiries@selectbiosciences.com
