Albert Gough's Biography

Albert Gough, Associate Professor, University of Pittsburgh

I received my PhD in Biophysics from Carnegie Mellon University where I developed tools and assays using fluorescence microscopy to study single cell physiology. As a Postdoc, I served as the Director of Imaging Technology in the Center for Light Microscope Imaging and Biotechnology at Carnegie Mellon University. In that role, I led a development project to develop an Automated Interactive Microscope for real-time 3D imaging of live biological systems. In 1996, I joined Cellomics, to automate light microscopy and enable the analysis of millions of cells under thousands of experimental conditions in a single day, an approach we called High Content Screening (HCS). As VP of Research and Development, I led the team that developed the ArrayScan line of HCS platforms now sold by ThermoFisher. In 2005, I joined Cellumen as VP of Informatics where I led the development of computational models to predict in vivo toxicity using highly multiplexed HCS data from in vitro liver cell models, now a product offered by Cyprotex. In 2010, I joined the University of Pittsburgh Drug Discovery Institute as Associate Professor of Computational and Systems Biology. Presently my research is focused in 3 areas: 1)The development of the Microphysiology Database for management and analysis of 3D microphysiology systems (MPS); and 2) the development and application of 3D liver MPS for toxicity and disease modeling; and 3) the analysis of cellular heterogeneity, and quality control in heterogeneous cellular systems.