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SELECTBIO Conferences Organ-on-a-Chip World Congress & 3D-Printing

George Truskey's Biography

George Truskey, R. Eugene and Susie E. Goodson Professor of Biomedical Engineering, Duke University

George Truskey is the R. Eugene and Susie E. Goodson Professor and Senior Associate Dean for Research in the Pratt School of Engineering. Dr. Truskey's research interests include cardiovascular tissue engineering, microphysiological systems, and the mechanisms of atherogenesis. He also studies cell adhesion and cell biomechanics, for which he focuses upon the effect of flow on endothelial cell adhesion to synthetic surfaces and monocyte adhesion to endothelium. He received a PhD degree in 1985 from MIT. He has been a faculty member in the Department of Biomedical Engineering at Duke since 1987. From 2003-2011, he was Chair of the Department of Biomedical Engineering at Duke University. He is the author of over 110 peer-reviewed research publications, a biomedical engineering textbook entitled Transport Phenomena in Biological Systems, six book chapters, over 180 research abstracts and presentations, 1 patent and 2 patent applications. He is a Fellow of the Biomedical Engineering Society (BMES), the American Institute of Medical and Biological Engineering, and the American Heart Association. He was president of BMES from 2008 to 2010. He received the Capers and Marion McDonald Award for Excellence in Mentoring and Advising from the Pratt School of Engineering at Duke (2007) and the BMES Distinguished Service Award (2012).

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Human 3D Skeletal Microphysiological Systems For Metabolic And Drug Toxicity Studies

Wednesday, 8 July 2015 at 18:00

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Skeletal muscle has a key role in mobility and energy metabolism and diabetes. Skeletal muscle is a major site of drug toxicity, causing weakness and muscle loss.   With an aging population sarcopenia is becoming more significant and alterations in muscle glucose metabolism lead to the onset of type 2 diabetes.  To provide an in vitro functional screen, we developed three-dimensional (3D) human muscle bundles.  The muscle cells formed striated multinucleated fibers and the engineered muscle bundles exhibit contraction in response to electrical stimulation and produce tetanus at frequencies above 20 Hz.  Contractile force increased with culture time over a five-week period. Further evidence of functional maturity include expression of mature muscle proteins and normal calcium handling.  Contractile behavior and myosin heavy chain expression were enhanced by addition of antimiRs to microRNAs 133a and 696.  Engineered human muscle bundles exhibited toxicity to cerivastatin at nanomolar does doses whereas toxicity to lovastatin was not observed until doses were in the micromolar range, above typical therapeutic concentrations.  Insulin-mediated glucose uptake was 1.5-2 times higher than glucose uptake in the absence of glucose.

Add to Calendar ▼2015-07-08 00:00:002015-07-09 00:00:00Europe/LondonOrgan-on-a-Chip World Congress and 3D-PrintingOrgan-on-a-Chip World Congress and 3D-Printing in Boston, USABoston,