Alf Månsson,
Professor,
Linnaeus University and Lund University Sweden
Alf Månsson is Professor of Physiology at Linnaeus University and affiliate member of the Nano-Lund research center at Lund University. He is an expert on myosin motor proteins and actin filaments of muscle, studying their functional properties using a range of biophysical techniques and modeling. He is also using these proteins in nanotechnological applications, from materials characterization, over biosensing to biocomputation. Dr. Månsson leads a small research team at Linnaeus University and has co-founded two start-up companies. He has published more than 70 peer-reviewed papers, given 15 invited presentations and been awarded 3 patents in nanobiotechnology.
Actin Filament Multiplication, Path Control and Longevity of Actin-Myosin based Nanodevices for Biosensing and Biocomputation
Wednesday, 30 June 2021 at 11:00
Add to Calendar ▼2021-06-30 11:00:002021-06-30 12:00:00Europe/LondonActin Filament Multiplication, Path Control and Longevity of Actin-Myosin based Nanodevices for Biosensing and BiocomputationPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Biomolecular myosin motors interact with actin filaments in utilizing the cellular fuel ATP to produce motion and forces, e.g. in muscle contraction and cytoplasmic streaming in plant cells. Both isolated motors and actin filaments have been chemically and genetically engineered for use in nanotechnological applications. In the devices, myosin motor fragments are immobilized on suitably derivatized nanoscale tracks for directed movement of actin filaments in network based biological computation or to separate analyte molecules and accumulate them on a detector area. For greater versatility of such nanodevices it is important to extend the shelf-life during storage as well as the longevity during device operation. For several applications it is also desirable to exponentially increase the number of filaments during operation, e.g. by repeated cycles of actin severing using gelsolin followed by elongation, and to precisely and remotely control the exact filament path through the network. Improved longevity requires rationally determined adjustments of the fluid environment and device fabrication. Here, I describe recent progress in these regards and their importance for improved molecular motors based nanodevices.
Add to Calendar ▼2021-06-28 00:00:002021-06-30 00:00:00Europe/LondonPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2021Point-of-Care, Biosensors and Mobile Diagnostics Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2021-06-30 11:00:002021-06-30 12:00:00Europe/LondonActin Filament Multiplication, Path Control and Longevity of Actin-Myosin based Nanodevices for Biosensing and BiocomputationPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2021 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
