Marya Lieberman,
Professor,
University of Notre Dame
Dr. Marya Lieberman is a surface and analytical chemist with over 60 peer-reviewed papers in the area of molecular electronics, DNA nanostructures, and low-tech analytical methods. She studied chemistry at MIT, obtained her doctorate in inorganic chemistry at the University of Washington, Seattle, and was a postdoc at the California Institute of Technology. Her current research focuses on paper millifluidic devices for chemical analysis in low-resource settings. These robust, inexpensive, and easy-to-use test cards help people solve problems outside the laboratory. Applications include detection of falsified and substandard medicines, monitoring nutritional supplement quality and population nutrition status, presumptive identification of illicit drugs, and evaluation of toxins in the environment.
On the Hunt for Sub-standard Antibiotics in Africa with Paper-based Analytical Devices
Tuesday, 27 September 2016 at 10:00
Add to Calendar ▼2016-09-27 10:00:002016-09-27 11:00:00Europe/LondonOn the Hunt for Sub-standard Antibiotics in Africa with Paper-based Analytical DevicesPoint-of-Care Diagnostics and Global Health World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Every antibiotic has an allowed variation of the quantity of active pharmaceutical ingredients (APIs), generally running from 90%-120% of the stated API content. Products which fall outside of these quality standards can harm patients and contribute to development of drug-resistant pathogens, so there is a public health imperative to find them and get them out of the market. However, quantitative analysis of medicines in low resource settings is difficult. Most countries in Africa don't have a WHO-prequalified pharmaceutical analysis lab. Others have such a lab, but lack capacity for the broad market sampling necessary to detect poor quality products. Paper diagnostic devices could help to fill this gap in analytical capacity. We are working with pharmacists in Kenya and Malawi using paper test cards and a neural network image analysis program to detect falsified and degraded products. However, these cards could not directly quantify active ingredient content, so they could not directly detect substandard products. We recently designed a new paper test card to quantify the content of beta lactam antibiotics in pills. I'll describe the chemistry in detail and discuss how we are implementing these paper analytical devices in a field setting to replace HPLC analysis. We are also exploring local manufacture of the paper test cards in Kenya.
Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonPoint-of-Care Diagnostics and Global Health World Congress 2016Point-of-Care Diagnostics and Global Health World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2016-09-27 10:00:002016-09-27 11:00:00Europe/LondonOn the Hunt for Sub-standard Antibiotics in Africa with Paper-based Analytical DevicesPoint-of-Care Diagnostics and Global Health World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
