Frederik Claeyssens's Biography

Frederik Claeyssens, Senior Lecturer, Materials Science and Engineering, University of Sheffield

Dr. Frederik Claeyssens is a Senior Lecturer at the Materials Science and Engineering Department at The University of Sheffield (U.K.). During his independent career Dr. Claeyssens established a materials microstructuring laboratory, and his main research explores laser-based 2D and 3D direct-write techniques for (bio)materials micro-structuring and the use of these structures in a range of different applications, e.g. tissue engineering, (bio)sensors, and microelectronics. Frederik Claeyssens has published papers in leading chemistry and materials science journals, he has 82 publications in refereed journals which have received 3059 citations, and an h-index of 27.

Emulsion Templated Scaffolds with Tuneable Mechanical Properties for Bone-on-a -Chip Devices

Thursday, 9 July 2015 at 08:30

Add to Calendar ▼2015-07-09 08:30:002015-07-09 09:30:00Europe/LondonEmulsion Templated Scaffolds with Tuneable Mechanical Properties for Bone-on-a -Chip DevicesSELECTBIOenquiries@selectbiosciences.com

An important self-assembly route for porous polymeric materials manufacture is emulsion templating via high internal phase emulsions (HIPEs) where typically a dispersed aqueous droplet phase is used with a curable pre-polymer continuous phase. During the curing process a foam is produced where the pores are interconnected (a polyHIPE). Here I will highlight our recent research efforts on using these polyHIPEs in combination with UV-based curing and stereolithography to make hierarchical structures where the internal porosity is governed by self-assembly and the macroscopic structure is constructed by additive manufacturing. These 3D structured scaffolds are produced with varying mechanical properties via changing the monomer mixing ratio to make the polyHIPE structures. These materials have an interconnected internal microporosity of ~10-50 µm, while the macroscale features are defined by the additive manufacturing process. Culturing of human embryonic stem cell-derived mesenchymal progenitors (hES-MPs) reveals that the scaffolds support osteogenic differentiation. Additionally, cells proliferate and penetrate into the micro- and macro-porous architecture. The presented hybrid manufacturing technique addresses the resolution trade-off between macro structuring with micro resolution, while maintaining user control over porosity throughout the process. This work illustrates the excellent potential of these hierarchical structured scaffolds for constructing bone-on-a-chip devices.

Add to Calendar ▼2015-07-08 00:00:002015-07-09 00:00:00Europe/London3D-Printing in Life Sciences ConferenceSELECTBIOenquiries@selectbiosciences.com

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