Dr. Djaballah has several years of industrial experience in early drug discovery gained over the years in pharma and biotech companies. He has extensive experiences in the areas of fluorescence technology, assay development, automation/robotics, HTS, compound & screening data management, software development & novel technologies. Dr Djaballah has been involved in developing and screening several targets in various therapeutic areas, including antibacterials, antivirals, antifungals, diabetes, CNS, cardiovascular, oncology & inflammation. He is currently the director of the high throughput drug screening core facility at Memorial Sloan Kettering Cancer Centre in New York. He obtained his BSc (Hons.) in biochemistry and biotechnology from the University of Birmingham, and his PhD in biochemistry from the University of Leicester, both in England.
Genomewide High-Content Multiplexed siRNA Screening Reveals Novel Control Junctions in the miRNA Biogenesis Pathway
Thursday, 8 September 2011 at 14:45
Add to Calendar ▼2011-09-08 14:45:002011-09-08 15:45:00Europe/LondonGenomewide High-Content Multiplexed siRNA Screening Reveals Novel Control Junctions in the miRNA Biogenesis PathwayRNAi and miRNA Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com
The talk will primarily focus on our recent efforts in screening for genes mediating miRNA biogenesis at a genome scale. We developed a multiplexed high content assay, validated the assay against a panel of genes reported in the literature to be strong modulators of the pathway, and performed a genomewide screen against the Ambion Arrayed Silence Select library covering approx 22,000 genes with on average 3 siRNA duplexes per gene. Our results reveal new players in the pathway and find no role for the previously reported genes DHX9, MOV10, TARBP2, and XPO5 in the miRNA biogenesis pathway.
Add to Calendar ▼2011-09-08 00:00:002011-09-09 00:00:00Europe/LondonRNAi and miRNA EuropeRNAi and miRNA Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2011-09-08 14:45:002011-09-08 15:45:00Europe/LondonGenomewide High-Content Multiplexed siRNA Screening Reveals Novel Control Junctions in the miRNA Biogenesis PathwayRNAi and miRNA Europe in MunichMunichSELECTBIOenquiries@selectbiosciences.com
