Therapeutic Antagonism of microRNAs with LNA: A Translational Research ModalityThursday, 19 April 2012 at 17:00 Add to Calendar ▼2012-04-19 17:00:002012-04-19 18:00:00Europe/LondonTherapeutic Antagonism of microRNAs with LNA: A Translational Research ModalitySELECTBIOenquiries@selectbiosciences.com LNA oligonucleotides are potent inhibitors of coding and non-coding RNA. SPC3649 is the first micro-RNA inhibitor in man and has shown safe and significant reduction in HCV viral load in patients. It will be illustrated in the talk how the clinical and pre-clinical data closely interrelate and how this has formed the basis for the fast and coherent development path of the drug. The SPC3649 case story suggests that LNA oligonucleotides targeting disease related microRNAs may enable translational research from bench to clinic. |