Jiang Zhong,
Assistant Professor,
University of Southern California
I obtained my B.S degree in Molecular Biology from California State University, San Jose and continued my graduate study at the University of Southern California (USC). I obtained an M.S degree in Computational Biology and a Ph.D. degree in Biochemistry/Molecular Biology at the School of Medicine from USC. The long-term goal of my research is to develop the knowledge base of gene regulation required to support manipulation of cell fate including differentiation and self-renewal. Specifically, my laboratory studies molecular signaling of cell differentiation with nanotechnology for manipulating and profiling many single-cells simultaneously. In contrast to the traditional approach of studying the lysate of a cell population, we study the molecular profiles of many single cells at normal or disease status to investigate gene regulation of cell fate.
Cancer-Associated Subclones Among Mesenchymal Stem Cells Revealed by Single-Cell Transcriptome Analyses
Wednesday, 9 October 2019 at 15:00
Add to Calendar ▼2019-10-09 15:00:002019-10-09 16:00:00Europe/LondonCancer-Associated Subclones Among Mesenchymal Stem Cells Revealed by Single-Cell Transcriptome AnalysesSingle Cell Analysis Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Despite the clinical benefits, detrimental effects of mesenchymal stem cells (MSCs) in clinical reports have been reported, in some cases fomenting tumorigenicity. Some of MSC subpopulations may be responsible for variation in the efficacy of bone marrow transplantation (BMT) and MSC-based therapy as well as tumorigenicity. Such heterogeneity of MSCs was not fully addressed until the arrival of the single-cell transcriptome technology. Recently, we report three discrete stages of osteogenesis based on a single-cell transcriptome analysis of individual MSCs during osteocyte differentiation. We identified a subpopulation of osteogenesis-resistant MSCs that have cancer stem cell characteristics. Further analysis indicated that the YAP1, ß-Catenin and Cadherin4/6 pathways involved in osteogenesis-resistance. Clinical surveys using 51 clinical databases across 6,965 patients revealed a correlation between YAP1/ ß-Catenin/Cadherin4/6 over-expression and cancer progression. This study suggested that a differentiation-resistant population of MSC with cancer stem cell characteristics is responsible for the tumorigenicity of MSC. Therefore, intervention of the YAP1, ß-Catenin and Cadherin4/6 pathway could potentially prevent tumorgenicity in MSC therapies by addressing the preexisting subpopulation of MSCs namely those differentiation-resistant populations associated with active YAP1-Cadherin pathway. Biologically active molecules targeting YAP1/ ß-Catenin/Cadherin could improve MSC therapy for a defined subset of patients by minimizing the tumorgenicity of MSCs.
Add to Calendar ▼2019-10-09 00:00:002019-10-09 00:00:00Europe/LondonSingle Cell Analysis Summit 2019Single Cell Analysis Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-10-09 15:00:002019-10-09 16:00:00Europe/LondonCancer-Associated Subclones Among Mesenchymal Stem Cells Revealed by Single-Cell Transcriptome AnalysesSingle Cell Analysis Summit 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
