Adam Pavlicek,
Associate Director, Bioinformatics,
Regulus Therapeutics, Inc.
Adam Pavlicek is Associate Director of Bioinformatics at Regulus Therapeutics in San Diego. Since joining Regulus in June 2012, he leads company’s computational efforts in discovery of microRNA-based drugs and biomarkers. Adam started his interdisciplinary training at the Charles University, Prague, where he received an M.S. in Theoretical Biology. He followed with a Ph.D. in Human Genetics from the Jacques Monod Institute, University of Paris 7. Prior to Regulus, Adam was a Senior Principal Scientist at Pfizer’s Oncology Research Unit in La Jolla.
Circulating microRNAs in Cancer: Tissue Origin and Correlation with Tumor Expression
Friday, 19 September 2014 at 09:45
Add to Calendar ▼2014-09-19 09:45:002014-09-19 10:45:00Europe/LondonCirculating microRNAs in Cancer: Tissue Origin and Correlation with Tumor ExpressionExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Circulating microRNAs are promising candidates as minimally-invasive biomarkers for tumor detection, disease monitoring, and patient stratification. Changes in serum microRNAs have been reported for many tumor types. However, how well global changes in tumor microRNA expression are reflected in circulating microRNAs is less understood. Using a mouse genetic model of HCC, we found that that serum microRNA pro¬files reflect both changes in the tumor tissues and systemic response to tumor burden. The serum-specific alteration included microRNAs linked to immune response, liver injury and other systemic responses to the tumor burden. Interestingly, most of the changes in both liver and serum are reversed upon inhibition of the driving oncogene. This pre-clinical proof-of-concept demonstrates that circulating microRNAs are suitable candidates for tumor detection as well as monitoring disease progression and treatment response.
Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonExosomes and Single Cell Analysis SummitExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2014-09-19 09:45:002014-09-19 10:45:00Europe/LondonCirculating microRNAs in Cancer: Tissue Origin and Correlation with Tumor ExpressionExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com
