Extracellular Vesicles in Cancer Signaling PathwaysFriday, 19 September 2014 at 16:45 Add to Calendar ▼2014-09-19 16:45:002014-09-19 17:45:00Europe/LondonExtracellular Vesicles in Cancer Signaling PathwaysExosomes and Single Cell Analysis Summit in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com Extracellular vesicles (EVs) are virus-sized membrane-enclosed vesicles that are released by cells via various mechanisms. Their contents reflect the molecular make-up of their cells of origin, and thus EVs show potential as biomarkers. EVs also serve as packets of signal initiators and transducers with effects proximal and distal to their release. Here we show that EVs from brain tumor cells have profound impacts on recipient cells (both tumor cells and normal cells) in terms of proteomic changes and induced signaling cascades. Most of these changes can be regarded as benefiting the tumor. The abilities of EVs to influence phenotypes and activities of recipient cells are likely among the most important functions of EVs. In a tumor setting, this knowledge may help us design better therapeutic strategies based on a continuous dynamic rather than static assumptions about the status of a cancer. |